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More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.
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Parma, Valentina; Ohla, Kathrin; Veldhuizen, Maria G; Niv, Masha Y; Kelly, Christine E; Bakke, Alyssa J; Cooper, Keiland W; Bouysset, Cédric; Pirastu, Nicola; Dibattista, Michele; Kaur, Rishemjit; Liuzza, Marco Tullio; Pepino, Marta Y; Schöpf, Veronika; Pereda-Loth, Veronica; Olsson, Shannon B; Gerkin, Richard C; Rohlfs Domínguez, Paloma; Albayay, Javier; Farruggia, Michael C; Bhutani, Surabhi; Fjaeldstad, Alexander W; Kumar, Ritesh; Menini, Anna; Bensafi, Moustafa; Sandell, Mari; Konstantinidis, Iordanis; Di Pizio, Antonella; Genovese, Federica; Öztürk, Lina; Thomas-Danguin, Thierry; Frasnelli, Johannes; Boesveldt, Sanne; Saatci, Özlem; Saraiva, Luis R; Lin, Cailu; Golebiowski, Jérôme; Hwang, Liang-Dar; Ozdener, Mehmet Hakan; Guàrdia, Maria Dolors; Laudamiel, Christophe; Ritchie, Marina; Havlícek, Jan; Pierron, Denis; Roura, Eugeni; Navarro, Marta; Nolden, Alissa A; Lim, Juyun; Whitcroft, Katherine L; Colquitt, Lauren R; Ferdenzi, Camille; Brindha, Evelyn V; Altundag, Aytug; Macchi, Alberto; Nunez-Parra, Alexia; Patel, Zara M; Fiorucci, Sébastien; Philpott, Carl M; Smith, Barry C; Lundström, Johan N; Mucignat, Carla; Parker, Jane K; van den Brink, Mirjam; Schmuker, Michael; Fischmeister, Florian Ph S; Heinbockel, Thomas; Shields, Vonnie DC; Faraji, Farhoud; Santamaría, Enrique; Fredborg, William EA; Morini, Gabriella; Olofsson, Jonas K; Jalessi, Maryam; Karni, Noam; D'Errico, Anna; Alizadeh, Rafieh; Pellegrino, Robert; Meyer, Pablo; Huart, Caroline; Chen, Ben; Soler, Graciela M; Alwashahi, Mohammed K; Welge-Lüssen, Antje; Freiherr, Jessica; de Groot, Jasper HB; Klein, Hadar; Okamoto, Masako; Singh, Preet Bano; Hsieh, Julien W; GCCR Group Author; Reed, Danielle R; Hummel, Thomas; Munger, Steven D; Hayes, John E
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In: Chemical senses, vol 45, iss 7 (2020)
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Abstract:
Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
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Keyword:
Adult; Aged; Betacoronavirus; Biological Sciences; Coronavirus Infections; Female; GCCR Group Author; head and neck surgery; Humans; Male; Middle Aged; Neurology & Neurosurgery; olfaction; Olfaction Disorders; Pandemics; Pneumonia; Self Report; Smell; somatosensation; Somatosensory Disorders; Surveys and Questionnaires; Taste; Taste Disorders; Viral; Young Adult
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URL: https://escholarship.org/uc/item/76p5k1rx
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More than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
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In: Chem Senses (2020)
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When having two names facilitates lexical selection: Similar results in the picture-word task from translation distractors in bilinguals and synonym distractors in monolinguals
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On Topic/focus Agreement and Movement
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In: Yang, Barry C.-Y.(2013). On Topic/focus Agreement and Movement. Proceedings of the 37th Annual Meeting of the Berkeley Linguistics Society, 37(37), 399 - 413. Retrieved from: http://www.escholarship.org/uc/item/50f0j7q7 (2013)
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Brain potentials during language production in children and adults: An ERP study of the English past tense
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On topic/focus agreement and movement
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In: Annual Meeting of the Berkeley Linguistics Society; BLS 37: General Session and Parasession on Language, Gender, and Sexuality; 399-416 ; 2377-1666 ; 0363-2946 (2011)
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What we mean, what we think we mean, and how language surprises us
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British-English norms and naming times for a set of 539 pictures: the role of age of acquisition.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2010)
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What remains of our knowledge of language? reply to Collins
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Age of acquistion, frequency trajectory and cumulative frequency in lexical processing tasks.
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In: IXX British Psychology Society Cognitive Section. ; https://hal.archives-ouvertes.fr/hal-00115061 ; IXX British Psychology Society Cognitive Section., 2004, Leeds, United Kingdom (2004)
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